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Insulin and a glucose monitor. (Carlo Allegri/Reuters)

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There’s no agnosticism associates of Congress will aggressively barbecue biologic admiral in today’s battleground audition on spiking biologic prices in the United States.

What will be fascinating is how the drugmakers try to avert accomplishments that abounding accept alleged indefensible.

“There is no adventure I anticipate they can acquaint that would absolve the amount increases they’ve been doing,” said Gerard Anderson, assistant of bloom activity and administering at Johns Hopkins University, who brash the Senate Finance Committee as its leaders organized the hearing.

The seven admiral on the console — from Sanofi, AstraZeneca, Bristol-Myers Squibb, Pfizer, AbbVie, Merck and Janssen (owned by Johnson & Johnson) — will apparently recite accepted industry arguments. They’ll point to the costs of analysis and development. They’ll altercate companies don’t abridged all of a drug’s annual amount because of rebates they acknowledgment to pharmacy middlemen. They’ll accusation these pharmacy annual managers and insurers for not accomplishing added to apartment barter from abroad costs.

“On average, 40 percent of the annual amount of medicines is accustomed as rebates or discounts to added entities in the accumulation chain,” Holly Campbell, agent carnality admiral for accessible diplomacy at Biologic Analysis and Manufacturers of America, wrote in an email to reporters yesterday. “Health insurers are animate added costs assimilate patients through deductibles, added use of coinsurance and the use of four or added tiers for decree medicines.”

But it’s one affair for the industry to avert ample amount tags absorbed to absolutely new “breakthrough” drugs, which amount companies abounding hundreds of millions of dollars to accompany to market. It’s addition to avert acutely approximate amount hikes on drugs acclimated for decades with little or no improvements to how these medicines work.

Senators will probably focus on these longstanding, widely acclimated drugs in their queries to the witnesses. Expect lots of questions about insulin, which is acclimated by 7.4 actor Americans with diabetes. Between 2001 and 2015, Eli Lilly, Novo Nordisk and Sanofi added prices for their insulins Humalog, Novolog and Lantus by 585 percent, 87 percent and 77 percent, respectively.

Director of the Center for Biologic Activity and Prescribing at the University of Pittsburgh:

Prices for insulin and added injectable drugs accept risen alike faster than for articulate medicines. The costs of articulate drugs added 9.2 percent from 2008 to 2016 while the costs of injectable drugs grew 15.1 percent during the aforementioned time period, according to a abstraction appear aftermost ages in the annual Bloom Affairs.

That aforementioned abstraction begin that decisions by the makers of brand-name drugs to accession prices are the primary acumen for the admission in U.S. biologic prices, not the expensive new therapies or improvements in absolute medications. For critics of the industry, the acknowledgment is simple: Drugmakers accession prices because there’s no one endlessly them.

“It was the little biologic companies that had one or two drugs, and they aloft the amount dramatically,” Anderson said. “The beforehand bankers said to Pfizer, ‘Well, if they can do it, why can’t you?’ ”

Other players forth the biologic accumulation alternation will be watching with contentment today as the biologic industry gets its about-face beneath the acrid Hill spotlight. They’re not absolutely accepting a chargeless canyon — anamnesis that aftermost ages the Trump administering angered pharmacy annual managers (known as PBMs) by proposing to ban the rebates they get from biologic companies — but for now, they’re blessed to be sitting on the sidelines.

“I anticipate it will be absolutely important for the CEO of Sanofi to explain what happened with insulin prices over the accomplished decade,” said Matt Eyles, admiral of America’s Bloom Allowance Plans. “What is so fundamentally altered today that enabled that amount admission to arise — I don’t apperceive that any of us accept heard a abundant annual from the industry as to why that happened.”

Shawn Martin, chief carnality admiral for advancement at the American Academy of Ancestors Physicians, said he’s additionally watching for drugmakers to be affected to explain massive amount spikes for drugs that were accustomed by the Food and Biologic Administering decades ago.

“It’s not necessarily the blockbuster or the drop drugs for attenuate diseases,” Martin said. “It’s the articles that accept three-, four-, five-decade activity spans that accept apparent cogent increases in costs.”

There’s annihilation the blow of the health-care industry — insurers, PBMs and providers — would like added than for drugmakers to be cornered on the affair of aerial annual prices. Annual prices aren’t about the final prices paid by pharmacies and insurers to advertise and awning a drug when the complicated arrangement of rebates and discounts is taken into account. But players all forth the accumulation alternation accept been abhorrent for creating the accomplished complicated arrangement that allows drugmakers to beforehand annual prices anytime higher.

“I anticipate you’ll see a lot of archimage tricks to get abroad from the actuality that they set the annual price,” said Erik Rasmussen, carnality admiral of government diplomacy for the American Hospital Association.


AHH: Washington accompaniment Advocate Accepted Bob Ferguson appear he will book a accusation adjoin the Trump administration’s latest aphorism targeting groups like Planned Parenthood. 

It’s the aboriginal accusation in what is abiding to be a bulk of acknowledged challenges from Democratic-led states over the final aphorism issued Friday by the administering to bar groups accepting federal ancestors planning allotment from accouterment abortions or aborticide referrals. The National Ancestors Planning and Reproductive Bloom Association appear a abstracted accusation bygone over the aforementioned issue.

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The Washington accompaniment Democratic advocate accepted alleged the aphorism a “transparent beforehand on Planned Parenthood” and charged it could absolute admission to medical affliction for low-income women in assertive regions. “Rural communities currently accept a curtailment of bloom affliction providers,” Ferguson said at a account appointment “This aphorism will accomplish the curtailment alike added acute.”

Ferguson said he would book the clothing as anon as the aphorism is appear to the federal register, the Seattle Times’s David Gutman reports.

“We will not acquiesce the federal government to behest what a provider can or cannot say to a patient,” Ferguson said. “This case is about agreement a political ideology, about agreement politicians in the room when doctors and patients are discussing health-care options. That is unacceptable.”

Scott Gottlieb, abettor of the Food and Biologic Administration. (Toya Sarno Jordan/Bloomberg News/Getty Images)

OOF: The Food and Biologic Administering wants to booty a afterpiece attending at whether decree opioids are absolutely able in abating abiding affliction and will now crave drugmakers to abstraction their effectiveness.

There’s little accepted absolute and controlled analysis on opioid effectiveness, our Post colleagues Lenny Bernstein and Laurie McGinley report. They abode some studies beforehand opioids can be abortive for alleviative affliction afterwards 12 weeks, and experts acquaint about the risks of addiction with abiding use.

“We are activity to appoint a authorization on absolute articles . . . to acknowledgment the catechism that bodies accept been assuming for years: whether you accept crumbling efficacy, and whether that crumbling ability can beforehand to addiction,” Gottlieb told our colleagues.

“The FDA acquired the ascendancy to appeal the capability analysis in a area of the Abutment for Patients and Communities Act, anesthetized in October,” Lenny and Laurie write. “Previously, Gottlieb said, the FDA could adjustment alone assurance studies of drugs on the market, but the new ability allows for capability studies as well.”

But one longtime analyzer panned the move, adage the FDA has the analysis it needs to act. “That’s absolutely what the FDA said to us in 2013,” Andrew Kolodny, administrator of Physicians for Responsible Opioid Prescribing, told our colleagues. “Five years later, we don’t accept the studies, and addition FDA abettor says, ‘We’re activity to do the studies.’ ”

OUCH: Vaccine critics are adverse a backfire amidst the improvement of a measles beginning beyond the nation.

It’s advancing from assembly in the District of Columbia who are investigating vaccine misinformation and the contempo outbreaks, captivation bipartisan hearings in the House and the Senate this week. It’s additionally advancing from the states, area assembly are introducing measures to accomplish it added difficult for parents to abstain vaccinating their children, our Post aide Lena H. Sun reports.

In Washington state, alike amid some anti-vaccination affect there, two measures are affective with bipartisan abutment through the assembly to prohibit parents from application claimed or abstract exemptions to abstain immunizing their school-age children. “In Arizona, Iowa and Minnesota, assembly accept for the aboriginal time alien agnate measures,” Lena writes. “In Vermont, legislators are aggravating to do abroad with the state’s religious absolution four years afterwards eliminating the abstract exemption. In New Jersey, area assembly accept approved abominably to bind religious exemptions, a bill to abolition it absolutely was afresh adapted on the Accepted Assembly floor.”

“[T]here is a growing accord for accompaniment authorities to accomplish the adventurous move to crave all accouchement to be vaccinated, with the alone barring actuality those who cannot be accustomed the vaccine for medical reasons,” Diane Peterson, of the Minnesota nonprofit Immunization Activity Coalition, told Lena.


Sen. Ben Sasse (R-Neb.). (AP Photo/Carolyn Kaster, File)

— The Senate fell abbreviate of the votes bare to beforehand a bill to abuse physicians who don’t accommodate medical affliction to accouchement built-in animate afterwards an attempted abortion. In a final vote of 53 in favor and 44 opposed, all but three Democrats voted adjoin a procedural motion on the Born-Alive Aborticide Survivors Protection Act, our Post colleagues Mike DeBonis and Felicia Sonmez report. The bill bare 60 votes to advance.

The bill, written by Sen. Ben Sasse (R-Neb.), approved to crave doctors to “exercise the aforementioned amount of able skill, care, and activity to bottle the activity and bloom of the child” as they would to “any added adolescent built-in animate at the aforementioned gestational age.”

“I appetite to ask anniversary and every one of my colleagues whether or not we’re accept with infanticide,” Sasse said on the Senate attic yesterday. “Are we a country that protects babies that are alive, built-in alfresco the abyss afterwards accepting survived a adulterated abortion?”

Republicans approved to beforehand the admeasurement afterwards Virginia Gov. Ralph Northam (D) dedicated a failed bill that approved to alleviate restrictions on abortions backward in abundance and New York Gov. Andrew Cuomo (D) active a new law decriminalizing the afterlife of a fetus if a abundant woman is assaulted and authoritative it easier to admission a late-term abortion. Aborticide rights supporters argued Sasse’s bill is meant to “dissuade doctors from assuming late-term abortions in the aboriginal place.”

“We charge alarm out today’s vote for what it is: a absolute beforehand on women’s bloom and rights,” Leana Wen, admiral of the Planned Parenthood Federation of America, said in a statement. “This legislation is based on lies and a misinformation campaign, aimed at awkward women and criminalizing doctors for a convenance that doesn’t abide in anesthetic or reality.”

Republicans answerable that by opposing the bill, Democrats were around condoning  that breed built-in animate afterwards attempted abortions shouldn’t get medical care. This affectionate of activity is almost rare, however, and the GOP-led vote was a political move advised to get Democrats on the record.

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Trump avant-garde that messaging in tweets aftermost night:


Former congresswoman Gabby Giffords, belted by Rep. Mike Thompson (D-Calif.), speaks during the addition of a bipartisan accepted accomplishments checks legislation. (Ricky Carioti/The Washington Post)

— Democratic assembly are affective bound to advance gun-control legislation, article they promised to do afterwards the midterm election.

This week, House Democrats are set to canyon a bipartisan bill acute federal accomplishments checks on all gun sales, Politico’s John Bresnahan reports. They’ve additionally appointed a vote on a admeasurement to extend the federal accomplishments analysis borderline from three to 20 business days, which John writes is meant to “close the ‘Charleston Loophole,’ which accustomed white abolitionist Dylann Roof, who dead nine African-Americans at the Emanuel AME Church in Charleston, S.C., in 2015, to buy a gun admitting awaiting abomination biologic accuse adjoin him.”

The fates of these bills in the Republican-controlled Senate is questionable, and both the National Rifle Association and Admiral Trump himself argue them. But the quick movement on the legislation is notable afterward Democrats’ attack promises and achievement in retaking ascendancy of the House, John writes.

Still, bisect remains. Just bristles House Republicans accept backed the accepted accomplishments checks bill.  House Minority Whip Steve Scalise (R-La.), who was afflicted in a cutting at a aldermanic baseball bold in June 2017, is one of the lawwmakers adjoin the bill.

— Meanwhile in New York, House Minority Leader Nancy Pelosi (D-Calif.) abounding the signing of a bill that will anticipate bodies from affairs or possessing accoutrements if they appearance signs of actuality a blackmail to themselves or others.

New York Gov. Andrew Cuomo (D) active the bill afterwards the accompaniment assembly calmly anesthetized the admeasurement aftermost month. The Red Flag Bill is the aboriginal such admeasurement in the nation to accredit ancestors members, agents and academy officials to seek cloister activity to stop addition from possessing or owning a gun.

“Today New York is appreciative to canyon the first-in-the-nation Red Flag Bill that empowers academy agents to do article aback they accept article bad is activity to happen,” Cuomo said at the signing. “We are allotment teachers, not by giving them guns, like the admiral wants, but by arming and allotment them with the law, so aback a abecedary or ancestors affiliate sees there is a problem, they can go to a adjudicator and get a court-ordered evaluation.”


— An cutting majority of American voters appetite Congress to abode health-care costs, according to a new poll appear by Morning Consult.

Adults say they are added acceptable to vote for a adumbrative in the abutting acclamation if they booty activity to accompany bottomward health-care costs, the poll found. And 91 percent of adults say it’s important for their adumbrative to do article about health-care costs. And the poll begin a majority of bodies beyond gender, age, assets and affair curve additionally say it’s important for their affiliate of Congress to abode health-care costs. 

The poll additionally begin there is advanced action to the Affordable Affliction Act’s bloom affliction taxes, with adults six times added acceptable to argue the bloom allowance tax than abutment it, four times added acceptable to argue the ACA’s medical accessory tax than abutment it and three times added acceptable to argue the “Cadillac Tax” on high-cost bloom affairs than abutment it. 

Sen. Charles E. Grassley. (Saul Loeb/Pool/Reuters)

— Sen. Charles E. Grassley (R-Iowa) announced the Senate Finance Committee will probe tax-exempt nonprofit hospitals. In a letter to the abettor of the Internal Acquirement Service, Grassley refers to the claim that these hospitals “must accommodated a approved association annual accepted acute them to accomplish contributions to their surrounding communities.”

“Unfortunately, according to reports, it appears that at atomic some of these tax-exempt hospitals accept cut alms care, admitting added revenue, calling into catechism their acquiescence with the standards set by Congress,” Grassley wrote. The letter references a 2017 adventure from Politico’s Dan Diamond detailing how hospitals additional their acquirement at the aforementioned time they cut aback on alms care.

The chairman’s letter alleged on the IRS to accommodate advice about its administration system, including advice about how abounding hospitals accept been advised to ensure acquiescence with standards.

— And actuality are a few added acceptable reads: 


The woman, a casual from Honduras whose character the bureau withheld, was six months abundant aback she was arrested abreast Hidalgo, Tex.

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Reis Thebault


The Aldermanic Budget Office badly scaled aback its estimates about a key allotment of the Affordable Affliction Act — estimates that helped derail the beforehand the abolition the law.

Glenn Kessler


“It is a affectionate of a new snake oil in the faculty that there are a lot of claims and not so abundant evidence,” said one expert.

New York Times

Researchers accept cigarette use apparently harms a accepted aspect of eyes biology, such as claret argosy or assumption cells.

Tom Avril


Bayer began arresting itself in a additional balloon alleging its Roundup weedkiller causes cancer, a case the aggregation is beneath burden to win to advice stop a bottomward circling of its allotment price.

Wall Street Annual



GAZA CITY, Gaza Strip (AP) — An opioid crisis has agilely advance in the Gaza Strip, accoutrement bags in the hell of addiction and abacus addition band of ache to the abandoned and bankrupt littoral territory.

Associated Press



Coming Up


President Trump says he asked China to ‘criminalize’ auction of fentanyl into U.S.:

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The Actuality Checker’s Glenn Kessler explains it doesn’t assignment aback politicians generally use differing “baselines” to activity favorable activity outcomes:

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